Suicide is the observable result of what is often a complex array of problems. Strong scientific evidence suggests that suicide risk is moderated by underlying biochemical abnormalities and environmental factors, which together can impact brain structure and function. Brain alterations that accrue as a result can place an individual along a path towards tragedy. In being a phenomenon that science has shown to involve myriad endogenous and exogenous factors, however, suicidality – and psychiatric disorders that confer increased risk – invites an integrative approach that may offer at-risk patients the very best opportunity for recovery. This three-module course will introduce an integrative model for suicide prevention, one in which the concept of suicidality as the result of underlying biochemical, nutritional, genetic, and environmental factors is explored. Research illustrating the benefits of nutritional supplementation to mitigate risk factors will be presented; evidence-based interventions will be described, and a treatment approach centered upon objective biologic measurement and a concept of biochemical individuality will be presented.